The following is an excerpt from "Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity":
Collectively, these data, further support our hypothesis that Nrf2 directly plays a role in the determination of both longevity and healthspan. Despite the well-documented relationship between Nrf2 and cellular protective mechanisms relevant to aging, surprisingly very few studies have evaluated the role of Nrf2 in mediating rates of aging and longevity. However, these indirect data outlined above, support our premise that the protective role of Nrf2 against toxins and tumorigenesis actively determines longevity and healthspan (Fig. 3). Many of the single gene mutations that have been shown to modulate aging could induce their effects through manipulation of this pathway and it thus may be a source of novel hypothesis testing in comparative aging research in this direction. Mechanistic dissection of this pathway and its regulatory role in aging will determine the validity of those hypotheses and may ultimately lead to intervention studies culminating in an extension of life and prolonged good health in humans.The subsequent link will take you to the rest of the research paper on Nrf2. Although a bit of a technical read, it is loaded with practical information on Nrf2 and how important this is for longevity and aging. This report is not connected with LifeVantage or Protandim, but is further confirmation how cutting edge this topic is becoming in the discussion of aging and disease prevention.
Before reading this report, it would be helpful to review the first video at the top of the blog under "How Protandim Works".
Nrf2, a Guardian of Healthspan andGatekeeper of Species Longevity